Surely this is a joke, right? Hunting bison in the Yukon ain't a drive up and shoot 'em proposition. These are some of the spookiest animals we have now, they hear an engine at 1/2 mile and they're GONE!!! Stalking on foot is the only way to get into reasonable shooting range consistently. You're hunting in the snow sometimes 2 feet deep and possibly in -40 deg C. You want to pack that heavy ridiculous POS to say you killed a bison with it, that's your business.
Of coarse the cartridge is capable, that's obvious, so is anything from the 30-06 up loaded with good penetrating bullets. Hell, I've killed 2 with a bow!!
If you intend to hunt the Yukon bison as a non resident then you MUST use an outfitter, he'll have a fit if you show up in camp with THAT rifle and expect him to take you bison hunting with it. I just don't understand what goes on in some peoples minds, pay big bucks to go on a non resident, guided bison hunt and then SUPER HANDICAP themselves with the likes of this POS.............HHHMMMMMMM..............