They will work fine, I used the 225s for years until I tried teh 250s, and I now shoot them.
Shot a few (2) med-large black bears with the 225s never shot a moose with the 338. The interbonds worked very well and exited with a good exit wound channel after breaking some shoulder bone on the way through and teh second was a front on shot that exited out behing the shoulder I must say they held together being quite impressed with this bullet. I never did recover the bullets so I can not comment on the wiegt retention however when skinning them out the wounds looked great. I can not see it working any different on those long legged bugers. I loaded both the 225s and 250s with H 4831, and now use H4831 SC and the same charge.
I did shoot one whitetail with the 225 interbond, never made a great shot hit him a bit high behind the front shoulder and the big 338 bullet slipped through with little expansion but the result was meat on the table. He just went 150 yards before he relized he was dead. I was amazed the lack of blood, but he filled up from the inside out.
I would really like to try TSX bullet in a 225 gr for bear. Maybe a project this summer to develop the load, however I have 150 loaded cartridges with 250s that will last me a life time for this cartridge.
Good luck.