There's certainly more than one way to skin a cat, and the big case .375s provide more possibilities than most. The problem the manufacturer has is that his reputation as a bullet maker will be ruined if his bullet fails on dangerous game, particularly buffalo, which is the only African dangerous game that is affordable to a hunter, who is a wage earner in his real life, and 2 buffalo can often be taken on a license. This means that more bullets will be flung at buffalo than at elephants, hippos, or big cats combined, and word of the success or failure contributed to his bullet will be more widely reported. If an expanding bullet fails to kill the elephant with a single blow, it could be reasonably dismissed as being an inappropriate application for an expanding bullet. If the bullet fails to dump the impala in it's tracks, no one will care. But if that bullet fails to expand fully at close range, and doesn't produce nearly 3' of penetration on a buffalo, potentially he's got some real problems associated with the future of his bullet. And if the hunter is injured or killed despite good bullet placement, and that failure can be reasonably attributed to poor performance of the bullet, our bullet maker could find himself at the losing end of a lawsuit. Such things have happened as with TBBCs when one failed to impress a grizzly, and Art Alphin's Lion Load bullet when it grenaded on a charging lion's jaw and hunters sustained injures inflicted by the game that was wounded with those bullets.
So the challenge is to design a soft point that will open fully and reliably and penetrate in a straight line through a very dense target, despite the relatively high impact velocity common to the .375s. Since 1912 or so, the .375 has attained the reputation for being adequate on game up to the size of elephants, of being a reliable buffalo killer, of producing lighting fast kills on lions and leopards, and of allowing the hunter to eat right up to the bullet hole on on medium sized and even small game. Impact velocity and target density combine to produce bullet expansion, yet the bullet that expands on a buffalo (inch thick hide, covered in dried mud, overlapping ribs, heavy supporting bones, and very dense muscle) might have trouble producing similar expansion on say an impala, which is not only frail by comparison, but is frequently shot at longer range resulting in lower impact velocities than might be the case on a close range stalk of a buffalo. The miniature species of antelope encountered in Africa, can be killed cleaning with virtually no bullet expansion, with little if any loss of edible meat, or severe damage to the trophy, which would certainly not be the case if a .243 or a .22 centerfire with typical game bullets was used. A bullet that produces excellent results on African buffalo could be expected to perform equally well on a Woods Bison in the Yukon, but as game weight and density diminishes, so does the degree of expansion. A broadside chest shot with a .375 on a white-tail might not impress someone who anticipates the reaction medium sized game has to the bullet impact from a high velocity small bore rifle.
Thus its not a big surprise that the performance of a partition type bullet might exceed that of a TSX, yet the TSX will work with boring regularity under a wide variety of circumstances. When in doubt, a TSX is never a bad choice, provided it shoots in your particular rifle. That said, my slug of choice is the heavy for caliber solid shank, petal nosed, pure lead,bonded core bullet, typified by the 380 gr Rhino. Yet I accept that this bullet might not produce a lightning fast kill on our barren ground caribou compared to say a .243, because there just isn't much there for the bullet to work against, but the caribou will die all the same, and there will be little blood shot meat. But when game weight exceeds a half ton, I doubt there is another bullet within caliber that can produce the wound channel volume that the 380 will.