The only powders I tried with the Rhino 380s in the .375 Ruger were: H-4350, Win-760, Re-19, and H-100V. Due to the fact that it wasn't my rifle, and that my supply of bullets was getting low, I didn't pursue the issue beyond that. Re-17 might be worth trying, but as a rule the choice of faster powders behind heavy bullets seems to produce pressure before the desired velocity is achieved and slower powders run out of volume before the desired velocity is realized. I expected Win-760 to produce the best results due to it's high loading density and a burning rate on par with 4350; it did produce the best velocity of all the powders I tried, which upon checking my notes indicates it was pushing the 380 at 2150; 50-100 fps below what I was looking for. The burning rate sweet spot for the .375 Ultra appears to be similar to Re-19 and I have achieved higher velocities across the board with the use of H-100V which seems to fall into that niche, so perhaps Re-17 is the right fit for the .375 Ruger.
It is interesting to note that when Gate and I have compared load data, my velocity is often lower. Now that might be due in part to the fact that we are using different chronographs or it could be that I'm at sea level where he is at higher elevation, or that much of my .375 Ruger testing was done in the low to mid -30s, or it could be a combination of all the above. 2150 wasn't the velocity I wanted so I didn't check to see if the load would shoot. If you just have to get 2200-2250 fps from the Ruger when loaded with 380s (the velocity that has been achieved with the H&H) I think you would have to chamber a long action rifle for the cartridge, incorporating a long lead to accommodate the bullet seated long so the shank does not enter the powder capacity of the case. The long lead would probably have a detrimental effect on accuracy when attempting to shoot any shorter bullets, but it would certainly optimize the performance of the 380s. This arrangement might allow you to approach 2300 fps. The fact of the matter is that I use the 380s for a specific purpose, but as a hunting bullet in the North American context, they have some limitations compared to good quality bullets of lighter weight.