I have two. The first is a Ruger Model 77 RSM ("Ruger Safari Magnum"), which is unfortunately discontinued -- but they can still be found used from time to time. For the price, I think it's a fantastic rifle. It's a bit heavy for a .375, but by virtue of that soaks up recoil very well. The rifle has some very nice touches, especially the milled quarter rib (which by itself on a custom rifle generally costs the full price of a RSM!), Turkish walnut, and ebony forend tip.
My only complaint about the Ruger is that the stock is a bit "clubby" in its feel. The forend is a bit blocky, and IMHO they got the pistol grip all wrong, as it has sharp corners on the top and has absolutely none of the smooth flow and feel that you would see on a classic British Express rifle. I appreciate why this was done, as it makes for a very thick grip -- and being very thick, it's very strong and must less prone to breakage. Like all things Ruger, it's build like a tank -- only in this case, a beautiful tank.
If you want a smoother, more rounded forend contour combined with gorgeous AA French walnut, a thinner and more flowing pistol grip, a bit less weight, a smoother action, a better trigger, and overall better balance -- and are willing to pay for it -- then buy a Kimber Caprivi. I did -- and that's my #2. Strangely, for a rifle at this price point, they didn't incorporate a quarter rib into the design. But otherwise, I'd have to say it's fully a step above the Ruger both in terms of overall design as well as fit & finish. But again, you would expect it to be given the price difference.
Of course, I appreciate that you're looking at either a laminated or a synthetic stocked rifle. I probably shouldn't even be talking to you!
But seriously, though -- if it were me, I'd definitely go with the Talkeetna. I'm really quite impressed with its wood-stocked sister.