Took me a while to find my old reloading notes but I finally did, I had a Ruger #1V in 223 years ago and found that even the 40gr. BT's would exit a coyote on broad side shots even at 250yds. And yes the wounds were gruesome.
I used RP cases trimmed extra long to allow long seating of the bullets. Win WSR primers, and Win 748 powder.
Loads ranged from 29.3gr. to 29.7gr.
velocities ran from 3560fps, to 3610fps.
I found no bullet at that time that would reliably stay in a coyote on broadside shots, perhaps some of the newer 35gr'er slugs would be of consideration.
The best hide preserver slug I ever used over the years was a 80gr. .243 cal FMJ in a 243Win, but they have there own issues with regard to marginal hits and built up areas.