Well it means the bullets are not starting into the case square (obviously) but the problem could be a number of things. As mentioned, case flaring. How much flare are you putting on them and have you experimented with different amounts? Also, depending on bullet shape and seating die it is possible the die is not able to stand the bullet up square. Roll crimping dies and larger bore cartridges with flat base bullets can suffer from this. Seating .45-70 with 350 gr RN Hornadys gave me grief because almost all were seated crooked and caused binding when chambered. Starting the bullets in a Lee classic loader then finishing in the press with a roll crimp fixed that particular issue. Before that I would seat bullets roughly 1/8" by feel then take the cartridge out and tweak the bullet by hand/eyeball it straight then finish seating. I know this doesn't fix your issue but hopefully it will get you pointed in the right direction.