I shot quite a few 'coons as a kid around the farm, and while you could kill them drop dead with a 22, shot placement was paramount with those little masked marauders. My weapon of choise was almost always a .410. In fact, the neighbour on the farm where I grew up would use a .410 slug when it was time to slaughter a cow for the freezer. Dropped 'em stone dead on the spot everytime.