Looking at the paper ballistics of the 45-70 cartridge loaded to Springfield Trapdoor specifications is not impressive.
However, a long time ago I learned that paper ballistics never killed a thing, and further more the animals can not read the ballistics, anyway.
A very long time ago my brother shot a big elk, with a 45-70, Springfield Trapdoor rifle, using a factory loaded 405 grain jacketed bullet.
He shot the elk at a 45 degree angle through the body and the bullet went clean through, killing the elk.
You are asking a theoretical question, because I doubt if there is a single sole on CGN who could answer your question from experience, which is, killing a grizzly with factory loaded rounds, in defence.
Long years ago, throughout the west, there were obviously oodles of grizzly bears dispatched with the 45-70 and low powered ammo.
Attacking grizzly bears have certainly been killed with a 30-30, so I can see no reason why factory loaded 45-70 rounds wouldn't be satisfactory, and far superior to a 30-30 class cartridge.