Google up Sandy Hook Tests of 1879. Check out some of Paul Matthews books such as "40 years With the .45-70" or his Black Powder Cartridge Rifle books. Also "Loading Cartridges For The Original .45-70 Springfield Rifle and Carbine" by a fellow by the name of Wolf (got mine from Buffalo Arms).
These will give you an idea of what is possible as far as BP loads can do.
What kind of rifle do you have or are considering? A falling block action such as a '74 Sharps can handle charges up to 110-120 grains. In the Sandy Hook tests they also tested an 85 gr load using a Trapdoor Springfield rifle so not really sure how high you could jack a load in one. In the end, the U.S. Army adopted a 55 gr load pushing a 405 gr bullet for use in carbines (to reduce recoil) and a 500 gr bullet shoved by 70 gr of powder for the infantry rifle. They determined there was no significant benefit to the 85 gr load so stayed with the existing charge. Personal experience; a .45-70-405 load in a carbine is quite a bear and Elmer Keith said the infantry load in a carbine was very punishing.
Personally I don't exceed 70 gr and often load up 55 as I only need them for short range paper punching. Usually use a paper patch bullet to reduce the possibility of leading. You don't want to try PP in a lever action.
If you go with Black, you'll need to control powder fouling somehow. There are a few tricks such as blow tubes, grease cookies and swabbing.