Well, the .45 Cowboy Special loads worked just fine at Grinchmas and the recent Winter Match at EOSC with the Square Circle Wranglers!
4.5 Gr Titegroup driving a 200 grain LRNFP bullet in my Ruger's (New Model Vaqueros), so, I'll be loading the rest of the brass with that charge.
I used the .45 ACP recommended starting charge from Lyman, but there was some differences between Lyman, Hornady and Lee in their Starting and suggested Max loads:
4.5 or 4.8 Starting to 5.3 or 5.4 depending on the OAL of the bullet;
4.8 to 5.4 Lee;
4.6 to 5.7 with Hornady.
As an old fart, I was cautious. (And it takes so long to heal)
Besides, I'm not shooting at T-Rexs!