With any revolver and cast bullets, you want the bullet to be slightly larger then each stage of its trip down the bore.
First off is the forcing cone, the bullet should be 1 to 2 thou larger then that. The forcing cone will swage the bullet down easily to the bore diameter. Hopefully, the forcing cone is larger then the barrel or else accuracy will be lousy.
From there, the bullets are sized for the bore and away they go. The standard 45LC bore is 451 but that is not the important dimension.
If you size specifically for the bore and that is sig smaller then the forcing cone, you will get blow by which leads to leading which causes all sort of grief.
It would be ideal if the bore was a .451 and the forcing cone exit was a .452/451 with an entrance of 0.452 to 454. That way you start with a 454/453 and have at it.
That is why your mold is a 454 diameter. If you use wheel weights, the finished size will likely be 453.
Jerry