I had a 450 Ackley for many years on a 602 Brno, it is a fun cartridge even if I had to stock it 3 times. Components are not at all difficult to get, you just make your brass from 375 H&H or even better from 416 Rem. You can buy dies from Huntington in the US and yes they ship to Canada, no problems. The Ackley is capable of an honest 100 fps better that the Lott and 400 fps over the 458 Win. In a 9.5 pound rifle the free recoil at 2550 for a 500 gn bullet is 93 pounds and the energy exceeds 7000 ft lbs. It's a blast to shoot and separates the boys on the range real fast, always take an extra 10 rounds to the range 'cause there are always guys who just gotta try it. My 450 would shoot clover leafs as long as I did my part and this never changed through 2 barrel bobbing incarnations.....26" to 22" to 20". Never got to chronograph the 20" final configuration, but only lost 90-100 fps from 26 to 22". Sorry but I don't recall which powder I used, but there is probably a better one now, as that was 25 years ago. I was going to use it on my very first Safari for my buff but it shed it's stock one day while practicing a mere 2 weeks before departure so I ended up taking my 416 Taylor instead. Unfortunately I never killed anything with it before we parted company.
I would recommend it whole heartedly, just for the fun factor.............
I am currently working on a 458 based on the 375/416 Ruger case, which I have high hopes for. Won't likely reach the Ackley level of performance but should equal the Lott and possibly slightly better. I have a donor rifle in 458 WM and my reamers, but I am now separated from my lathe for the winter..........unless I buy a new one.........HHHMMMMM....
Boomer.....I have never experienced the rim/case mouth problem you have alluded to, but in my various 458s I have always crimped into the cannelure heavily, even my Ackley so I've never had this issue. With this and usually heavily compressed powder charges I have never had bullets driven into cases either, which I'm told by another 602 Ackley shooter will happen quite frequently if you don't crimp. What with 5 under in the 602, I believe him. That's a lot of magazine slam for that 6th round.