I don't believe meat damage would be an issue with the 454 casull out of a rifle... arnt they somewhat comparable to a 44 magnum round?
jus cos its got an unusual name , or different sequience of numbrs, doesn't neccisarily mean it will perform much different to what is out there today.
From what I gather
A Heavy, FN or RN projie at very moderate speeds from the get go.
would act very similar to another Heavy, moderately paced FN from a .44 mag? I believe
WL