You'll also need an upper receiver with a "big bore" ejection port. The 2nd-gen upper receiver that MRA is working on will have this feature. There are also other options like the Anderson big-bore upper.
Ah, thanks TNA. I guess my mindset is on my SLR, which MDI supposedly modified to be compatible with the big cartridges (.50 Beo, .458 SOCOM, etc).