The .458 is a surprisingly versatile cartridge, for North American game. I've used mine on just about everything from whitetail to moose, without issue. It's simply a matter of matching bullet/load, to the intended game. A good middle of the road for most game: 350-400 grain bullets Easily tackles most hunting situations.
I fully agree with Chuckbuster. When it comes to handloading, the .458 is capable of a wide variety of uses. Only downside, can be the rifle's weight. My custom rifle....built on a Mauser action, tips the scales at 10 1/2 lb. Can get a bit tiresome lugging that thing around over a long day. But, touch off the trigger and there won't be much tracking to do.
Al
ps: I like the 350-grain Hornady RN, too. Versatile bullet. Likewise: 350 grain mono metal Barnes-X bullet. Consistent expansion and performance.