I had a nice original Trapdoor once. The groove diameter was .462. It would be well worth slugging your bore. It was hard to find a mould that dropped them large enough so I ordered a custom mould from Accurate Molds. 46-500F that drops a 500 grain bullet that can be used in either the original Trapdoor or an original Winchester 1886. You specify what size you want to size the bullet to and your alloy and he machines the mould accordingly.
This is the probably the most important observation about original trapdoors so far. I have been saying this for years and have been shooting the old originals since the mid 1970's. We found an old Lyman #457193 mold that threw a 0.463 bullet weighing 420 grains with wheel weights. This bullet has been a consistent match winner in BP cartridge matches across three provinces and Montana. The old TD was an 1889 vintage Model 1884 all original gun with the Buffington rear sight.
With the new trapdoor repros it is best to slug the bore first, as mentioned here already, then tailor your loads from there. Do not bother with chasing the extremes in bullet weights (500gr or 350gr, etc). We tried all of those weights, then returned to our old 420.
Historical note here. The Frankford arsenal loading for original 1873 to 1873/79 trapdoor was a 405 grain bullet, with 55 gr powder for the carbine and 70 for the rifle. The 500 grain did not officially come out till the early 1880's. This was after Springfield produced the experimental "Long Range Rifle" (an incredibly rare gun), which was chambered in 45-80-500 using a 500 grain bullet. The performance of this rifle and cartridge combination was of sufficient merit that Frankford experimented with using the bullet in the 45-70. It did very well and was introduced as standard for the rifle in the mid 1880's.