In a variety of weights of cast bullets, for light loads for the 500, Unique has worked well for me. For heavy loads, cast and jacketed, H110. Because of some ignition problems with some of the earlier production brass using H110 and powders of similar burn rate, the later cases utilized large rifle primers.
A source of info you may find helpful would be some of the efforts of John Taffin of the American Handgunner, January/February 2004.
In my experience, anything I've put through the 500, cast or jacketed, both heavy and light loads, they all seem to do well on paper.
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