Great conversation here.
I just built a 6mm AI and went through the whole gammet of what to build; 243 AI, 6mm AI, or the 6mm-284. Keeping in mind I wanted a hot-rod 6mm.
The 243 AI basically gets the same velocoties as the plain 6mm rem. The 6-284 had appeal, but burning more powder for maybe 50fps, and the 6.5-284 is well known as a barrel burner, so the 6mm-284 could only be worse. Also heard it can be a little finicky to find a load for?
This left the 6mm AI, 11% more case capacity than the parent case and supposedly the long neck on the 6mm case will provide some protection and not burn the throat as fast as the 243 AI.
One thing- If you go with the 6mm-284, or the 6mm AI and plan to shoot the VLD bullets go with a long action. My reamer only has .050fb, and I had to go with a wyatts extended mag box to get the 87 grain Vmax to feed out of a Rem short action where the bullet wanted to be.