I shoot 200&250 grain Hornady interlocks in round nose and spitter styles out of my .35 Whelen. No problems. Deer die quickly and I haven't recovered a bullet yet.
I've shot four deer so far. A doe running uphill quartering away about 40 yards. Caught her in the near shoulder and exited far side of the neck. She dropped about 30 yards from the shot.
A spike a few years ago, hit him high and the the rear a bit, hitting the liver. He dropped like a rock, by the time I came off the ridge, he was back up and walking, but not stable. I shot one through the ribs, taking out a rib on the far side with a 1x2.5" exit wound. First shot was about 40-45 yards.
My buddy got the first shot into a small buck last year. We gave chase for a half mile. I out him up three times, finally getting one in behind the near shoulder and exited the chest as he was quartering away. We recovered him 100 yards from there.
My last deer was also last year at 57 paces. Big 8 pointer walking broadside. Fired the first shot, no reaction. Fired a second shot, no reaction. Fired a third shot in the neck, dropping him in his tracks. First two shots hit him in the liver and both lungs. All three were complete pass throughs. There was also blood everywhere on the far side of him. He was DRT, but he just didn't know it at the time.