Most pistol powders are linear in their burn rates relative to charge weights, so start with a light load (like 4.3 gr.) and run it over a chronograph to get a base line. Once you have this data you can do a linear projection to get what charge weight you will need to make whatever power factor you want. Power factor = (speed in fps) X (bullet weight in grains)
So divide your actual power factor into the power factor you want, and multiply this number by charge weight in grains. That will give you the charge weight you need. For example:
Target power factor (130) / actual power factor (120) X charge weight (4.2) = 4.5 grains.
These are not real numbers. They are meant only for demonstration purposes.