A friend of mine shot a black bear with a ballistic research industries slug in 12 gauge they were commonly called BRI sabot. I can't recall the weight of the slug for certain but it was around 450 gr. and I believe the diameter of the slug itself was about 50 caliber, another thing was the slug was not lead it was something else that was much harder.
We were hunting over bait during the spring hunt, anyhow, We were in the treestand and this big ol bruin come walking in snapping and popping his jaws and its worth noting that he was a big bear probably in the two hundred fifty pound range which is a really nice size bear for the area that we live in. So the bear was coming in on a bit of an angle and facing us, the slug went in on a slightly downward angle about 3/4 up the shoulder blade and went all the way through punching out just before the hind quarter on the off side, on the way through the slug smashed the shoulder blade and a couple of ribs, made a bloody mess in the chest cavity and dragged a bit of the guts out the exist hole, It was quite impressive to say the least however the bear did not fall over and die right there, it took off running full speed ahead. We found it dead about 150 maybe 200 feet from we're we shot it.