I’m familiar enough with Litz and have gone down the rabbit hole on some of his publicly available info and that of others in his field. And sure while you can still have a useable rifle when the reticle isn’t in line with the bore axis, you can’t argue that particularly when using canted rings/bases, the reticle needs to be plumb to the bore axis.
The argument for needed the reticle plumb to the bore is that orherwise, when you dial your come ups to go from say 100 yard zero to distance X, you’ll also have an impact in windage (assuming 0 wind) because of the angular offset of the bore relative to the plumb line of the reticle by the time you true up your reticle. Ie because the reticle isn’t plumb to the axis you’ll see changes in the L/R impact of the bullet as you move out in range without even making any adjustments to the windage turret. Sure you can build your DOPE once you’ve shot at various distances and know what that windage error is at various distances, but then again why allow that to be a variable on top of already having to read wind when the solution is simply to get the reticle plumb to the bore?