At one time Speer made two different types of bullets. The traditional cup and core which wasn't HOT CORE.
The Hot Core Speer hold up as well on game as any other good cup and core bullets.
BONE shots are extremes for any bullet to withstand, especially at close ranges.
OP, if you're considering using the Speer Hot Core bullets, I would suggest you use HEAVY FOR DIAMETER BULLETS.
For instance, if you normally use 150 grain bullets with premium bullets, step up to 165 or 180 grain bullets with cup and core, even the hot core type.
Remember, other than the Hot Core bonding, which is very similar to the Hornady interbonding, without the internal bands, these bullets are older tech.
That being said, they are at the top of the ladder of that older tech and are very effective bullets when chosen properly for the conditions you intend to hunt.
If you're taking longer shots out to 300 yds, you will want a bullet that will penetrate as well as expand properly on game.
On the other hand, if you're hunting out of a tree stand or blind where shots can be up close and personal, then you want a bullet that will stand up to extreme stresses. If you're going to use cup and core, the older ideology comes into play and you need to follow Elmer Kieth's advice, BIGGER IS BETTER.