I picked up a .40 last year after kicking around the idea of getting one for years. I will admit that the grip felt a little odd to me when dry-firing at home–the "hump" at the back felt odd, and the grip itself was a little slippery, too. But once I shot it it felt great—there were no issues with comfort at all. I've had other pistols that felt similarly odd but shot great at the range –the H&K P7 is one example. It was surprisingly accurate too—I shot all rounds at 10m as I find it's a good distance to try a new gun out at. The first group of ten were OK, but the groups tightened up as I got used to the pistol. There was some "punch" to the recoil, of course, but little muzzle flip. I like it more than I thought I would!
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