No, but I have tried it on a friends 45/70 (Bushnell TRG 25 I believe). Always felt that it would be fairly reasonable to use on something like that, or a small game rifle. Stuff where the shots aren't really likely to be far, given the usual dot sizes. 40 yards or so would be about as far as I could reasonably make use of that on a 22 RF for head shooting chickens I would think, but 100-150 yards on big game with a slower moving cartridge wouldn't hamstring you much I don't think.
I do have one on a Ruger 22/45 Lite, and it is fairly spectacular in that application.