I think if I was going to use a hot loaded .25/06 or .257 Weatherby for deer or caribou I'd prefer the AB, and if shooting a .250 Savage or a .257 Bob, I'd prefer the BT. If I was moose hunting, with either class of cartridge, I'd choose the AB. If I was wolf hunting with either class of cartridge I'd choose the BT. To the extent possible, match the bullet to the weight of the game, and to the impact velocity you anticipate. The larger your game, the more penetration is an advantage, the tougher the bullet, the deeper the penetration you can expect. The higher the velocity, the more violent the terminal performance of the bullet, which in turn is modified by the design and construction of that bullet. The year I got my .375 Ultra, I got creative and loaded some medium game ammo, and I still have a few. In those days Nosler made a .375/260 gr BT, and I loaded them to a modest 2600 fps. For the purpose I had in mind, the BT was a good bullet, and the modest velocity provided a flat (enough) trajectory, whereas today I'd have to load an AB to full velocity to get similar bullet performance, but the level of power would be out of balance with the size of the game the BT load was intended for.