I have used 150 and 168 gn TTSX in my 300 Wby briefly and did use the 168 TTSX bullet and load combo to take my Altai Argali..........but have since gone back to old school of weight and BC over fancy bullets..........I load 200 gn ABs and 200 gn Parts for my 300 now and probably will end out my hunting days with these bullets in this rifle and caliber. There just is no down side to this load, and it shoots just as flat over reasonable hunting ranges and hits like lightning..........I can see no upside to the Barnes in my 300 Wby, and I'm not cleaning copper fouling out every week using the Noslers.
The only rifle I have used the TSX bullets in that I still do, and will continue to do, is my Rem 700 in .375 H&H. It is a penetrating, killing machine with the TSX and shoots sub MOA consistently. It also shoots very flat for caliber and makes hitting critters out beyond 300 mtrs with this rifle and load not just possible, but actually quite easy. I'm getting 2925 fps with the 270 gn TSX, which is enough to open it up within the ranges I use this rifle but seems to fall below the nasty, accuracy destroying, copper fouling threshold that I have experienced in several other rifles, of higher velocity.
And before a group of you jump all over me and say 2925 isn't possible safely in a 375 H&H with a 270 gn bullet, let me assure you in this rifle it most certainly is. Not only is it safe, I have used it in 55 degree heat in Zambia and equatorial heat and humidity in Congo and have never even loosened a primer pocket. And this isn't even using W-W brass, it's using R-P brass, if I could get some W-W brass for it I could likely get another 75-100 fps from it.
I actually did pick up 200 new W-W brass in 375 H&H but I will not be using it for the H&H, I'm saving it specifically for my 340 Wby, where I will need the extra capacity and toughness of the W-W brass...........

