I have loaded multiple thousands of rounds of 45/70 with everything from 350-525 grain bullets, cast and jacketed. I have never used anything but IMR 4198. There are many powders that will work fine but I have never found it necessary to try anything else.
Many shooters of the great 45/70 will recommend H4198, IMR 3031, Reloader 7. I know a few guys that won't talk to me about loading for the 45/70 because I prefer smokeless powder and they shoot pure black with paper patch cast bullets, but they can hit a 3 foot circle at 1000 yards with iron sights.