best semi-auto for the larger handed gentleman

A full size Sig like a P220 or P226 would be my recommendation. But I am quite biased. The M&P's can have a pretty big backstrap put on I believe, and a Beretta 92 fills the hand quite nicely as well.
 
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Reliablity: With full loads, yes.
Accuracy: Yes
aftermarket parts: What are you looking for?... But it does come in a plethora of finish...
Cost/value: The smile per/$ is pretty good...
Not a 1911 frame: Nope...
 
Glock Gen 4 with Large backstrap
CZ97
SIG P226 or P227
G21 or G20
S&W M&P with large backstrap
HK MK23
USP, P30L or HK45
 
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