A 100g .243" interlock is still going 2200-2300Fps at 300yards.
That'd still give it in the neighbourhood of 1000-1200 ft/lbs of energy. Probably fine for most deer - but it should at least get you thinking a little.
What's the penetrating power of a 100 grain bullet at that speed/energy? How much would it take to knock that bullet around, if it hit bone for example? WOULD a good mushrooming bullet go all the way thru a good sized deer, especially if you clipped ribs going in and/or out? The 'shock' wave isn't going to be fantastic at that speed on that size a bullet - your chances of disrupting cns systems if the bullet passes close go down. The deer may still die, but will it get a lot farther and be a harder tracking job? Are you any good at tracking?
It should make you aware that you're beginning to get CLOSE to a 'marginal' performance profile, where more things have to go right than wrong for optimal results. Obviously, on deer you're still doing pretty good, but it should be a bit of a warning to take only 'sweet' shots, and not push the envelope too far on a quartering shot for example. It might also make you think just a little about tracking - is that a good shot to take right at dusk in a heavily wooded area, vs dawn in a fairly open area where you'll have all day to look? Are you going to get much of a blood trail?
If you were using it for moose or bear you'd think even harder - it'd probably be a bad idea to shoot because even tho you stand a GOOD chance of killing the animal, the chances of something going wrong are starting to get pretty high.
I'm not offering an answer to any of those questions, but it demonstrates how being AWARE of it can help you make better shooting decisions. It depends on how well you know your gun and your hunting/tracking/shooting skill, how well you know your game, and what level of 'risk' you're willing to accept. A newbie hunter may wisely decide that 300 yard shots with a .243 are not a great idea. An experienced hunter who knows his load and what it can do might not even think twice about it.
It's always good to think about.