The Ruger 22/45 has a polymer frame with fairly heavy steel upper. The time I hefted one in a store I didn't like the overall balance due to this compared to the Buckmark that seems to settle into my hand with a much nicer balance.
The other Rugers with the Luger like grip angle are steel and don't suffer from this odd balance issue.
Try holding all three of them along with anything else you can find and make up your own mind.