I'm in the midst of this experiment right now. So far I've used 53gr Hornady Match, 50gr Vmax and 60gr Ballistic Tips. Shot two coyotes with each load so far. The only one to not exit so far is the 53gr Match, though it did leave a nasty entrance on one. The others each had one exit and one not exit, though the 60gr left a much smaller exit. All coyote's dropped where they stood. My friend used one of my 50gr Vmax loads to shoot a nice yote this weekend at maybe 70 yds, facing dead on. Somehow, the bullet or at least a fragment exited out the back leg. Tiny exit,so probably a fragment.DRT as well. As for the Varmint Grenades, I'm a bit leery on the 36gr. My friend shot them in his 22-250, and they were very accurate, so he tried them on coyote's. Shot two, the first went down but yelped and spun for a long time, to the point where he was going to shoot again. He saw another one coming to check out the ruckus, so he shot that one to. It went down, then got back up.Shot it again,same result. Shot it again, same result. In all, he shot it five times, the last being a finishing shot at close range in the head. It seems the bullets where not penetrating deeply enough at that speed, more or less blowing up. Might be okay in the 223, but with so many other good bullets out there I wouldn't bother. The 50's might work, but they are quite long and slower twist barrels may not stabilize them. Saw them keyhole out of the same 22-250 used for the 36 grainers.