A little .22 is a good thing to have.
But for centerfires, you should try them out.
At the very bottom of the cost (and, if you ask me, quality) ladder you have Norincos. They're Chineese knock-offs of major pistols, dirt cheap but having seen some of them, you can tell that they're not made to the same standard as the pistol they've orginigally copied.
At lower costs, you have the Glock (I personally don't like them), Springfield, Smith and Wesson M&P and CZ pistols. And don't discount the EE forums, that's where I got my first centerfire pistol.
Berettas and Brownings are more mid-range in price, with the lower end HK at the top end of the mid-range.
Sigs (except maybe the factory refurb ones), Para-Ordnance, STI, those tend to be a lot pricier.
So, if buying new, you're looking at anywhere from 650$ and up unless you go for a Norinco. But a lot of gun stores have used pistols in stock and those are at a decent price.
Do your homework, and try some pistols out at your local range. Asking nicely and supplying some factory loaded ammo so you can feed whatever you've borrowed is never a bad idea either.