The nice thing about the .223 is that it can be had in the mini-Mauser bolt guns from CZ and SAKO. Particularly if you are looking for a walking varmint rifle, these little rigs are pretty sweet. The .22-250 has the advantage of speed over the .223, but its larger cartridge body, requires a larger action, the larger powder volume means you must use more powder to achieve equal performance, and the difference in trajectory within 300 yards between the two cartridges doesn't mean much. Frankly, the .243, not the .22-250 would be my first choice beyond the .223 (or the .222 or the .222 magnum) as the .243 can drive a 55 gr bullet out to 4000 fps, its suitable for the smaller varieties of big game with 90-100 gr bullets, and makes an impressive long range target cartridge when loaded with 115 gr VLDs.