Before you spend a ton on a gun that only shoots 250gr bullets, seriously look at custom. I'm running an Ackley Improved 338Nesika with a 1 in 9.250 twist and I'm having awesome success with and including 325gr hunting rounds from Wild Cat. Limiting your options when you're spending that kind of money is defeating unless all you're after is the 1000yd mark in which case any off the shelf crazy expensive 338LM will do. Check out the Band a gong thread for more on the power of the 338LM AI.