Charge for 45 colt using Hodgdon H110

H-110 is meant for heavy loads in revolver ctgs., such as loads used in Rugers, Tc,and Freedom Arms....not meant for CAS loads.
 
If you had a really hard cast bullet, and were loading it on the heavy side, you'd probably be able to find something that would work. For a cowboy bullet, which is likely a fair bit softer, which you're going to want to run something lighter, you'd be best finding a different powder. Unique, makes a very good choice, in almost all light loads, as does Bullseye. Basically any reasonably fast powder, would work well for what you want.
 
The absence of a crimp groove also makes the Hornady bullets unsuitable for heavy loads, besides the fact that they're very soft swaged lead.
 
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