The single shot makes for an excellent general-purpose bench/varmint gun. The Savage bolt offers simple and unique possibilities. I have even seen conversions of the Remington 700 bolt to a Savage bolt head system.
Pre the availability of the custom actions we have available to us today, they had more use but since they are still made to mass production tolerances (at least compared to custom actions today) they are not a favorite for optimal accuracy and often require rework.
Hand tight barrels generally work in limited applications and then for best repeatable accuracy are not recommended. Many a BR shooter has fallen victim the ills of a hand tight then loose barrel. Keep in mind this is with a fully custom and accurized action/barrel- system and not a factory action coupled to a barrel machined to BR standards

. Some good reading on the subject (and others) is the book - "Rifle Accuracy Facts" by H. R. Vaughn.
Listed below are a few other things not mentioned. They will impact the degree of success in "hand" tight and wrench tightened barrels:
- The action (Nearly as important as the barrel). If you planning on using the "hand tight" technique with a factory produced action good luck. The receivers as a general rule are not machined to acceptable levels. The mating surfaces are of concern, I.E. the receiver face where the barrel shoulder mates to the receiver, the axial alignment of the receiver threads with receiver bolt raceway, and the receiver/barrel thread fit/class.
- On a typical sandwiched lug system (barrel, recoil lug, receiver) the lug needs to have mating surfaces parallel. Factory produced lugs are generally not of the same quality and surface finish as custom produced lugs. Uneven bearing will result in a barrel not mating properly with the receiver. As the barrel vibrates/whips it will loosen (pending caliber and physical contour of the barrel).
- The physical length and weight of the barrel. This will influence the stresses the receiver/barrel joint will see. Toss in the wide range of magnum capacity cartridges and your asking for trouble with hand tight barrels...
Already mentioned (a very good point) is barrel twist in relation to the tenon threads - cw or ccw. Couple this with fast twist, high capacity cartridges with heavy bullets and look out...