In terms of performance vs. ammo cost, for coyote hunting in Newfoundland, the .22-250 wins hands down. Has that extra range to reach out there beyond the .223. Factory ammo is only a couple of bucks more expensive than the .223 and its accurate as hell. I wouldn't feel undergunned with a .223, but if I had my druthers, the .22-250 is the way to go.