I have a CZ 457 Varmint in 22WMR,
Best groups average close to .25" at 50 Yards with CCI 40gr JHP and CCI 40gr Game Point - consistently both about the same for repeatable accuracy.
I did install a Timney trigger in this gun and set it at 8oz on my trigger pull gauge.
Also poor results with the Federal 50gr load - possibly too heavy considering twist, velocity and deceleration in the transonic range.
I think that the 50gr load could be under-stabilized being 20 per cent heavier than 40grs in the standard twist rate.
But I got better results with Federal 40gr loads, close to CCI but never as good.
I find that whether I'm shooting 22LR or 22WMR best results are always obtained in this rifle with 40 gr loads using top quality ammunition.
I found that Winchester 40gr WMR is a waste of money for me and I don't experiment with lighter grain loads as I do not intend to use them on game, varmints or whatever needs to be shot.
I have done extensive penetration testing with the CCI 40gr Game Point and settled on this for my default loading, but would switch to the CCI 40gr JHP for more destructive/explosive performance on smaller varmints.
I also have a CZ 457 LRP match barrel mini-set in 22lr and again with top quality 40gr ammunition (Lapua, SK, Eley) the gun shoots better than I can hold it.
I have been shooting for more than 55 years and I believe that the 22WMR is a very under-rated cartridge for many applications.
Of course this is just my personal experience and others will have more to offer on this subject.
Regards, D.