Had one and thought it fit well (large hands) but couldn't shoot it straight. Felt off balance when recoiling (developed a flinch-yet I can shoot full bore 357mag and 40cal no problem)... sold it after 200 rounds. Shoot one before you buy. I didn't like mine. Everything is a personal decision, what works for one may not for another. Trial and error.
I like the Sig ergonomics better than CZ, sold my CZ97 and 75. Have 2 Sig226's and a 220 on the way.
Personally if I would purchase a 45 it would be a Sig220, HK45 or a good 1911.