I've got far, far less experience shooting game than many on here and other forums, but I believe I see a distinct trend in the threads and user reports I've seen.
There seems to be a desire among some hunters to chase the bleeding-edge long-range ballistics enjoyed by target shooters. That's understandable; after all, who doesn't want the best performance available?
I think the question becomes one of exactly what type of performance are you after? Is it about hunting, or shooting?
I've seen enough anecdotal evidence to convince me that the currently available crop of "long-range hunting bullets" are so limited in their versatility, that they're not at all appealing as a hunting bullet for me. I can't imagine a scenario where I would be faced with shooting opportunities ONLY out at the ranges where these types of bullets seem to perform acceptably.
When the mathematics of ballistics are so well known that they're available on your smartphone, and optics available are generally so well-made as to ensure confidence in adjustment and resolution for longer-range shots, what is the point of using a bullet which has such a narrow margin of ballistic advantage over its more conventional brethren, at the expense of the wide margin of versatility offered by the same competition?
It seems largely self-defeating to me, and I'll stick with GameKings, Partitions and Triple-Shocks for my bullets.