I've used 243, 30-30, 44 mag, 6.5x55, 50 cal muzzleloader and 308 and they all work fine. The only caveat I would add is that 44 mag had a less forgiving trajectory, dropping faster than the others, and required more skill at range estimation and discretion in passing up a shot. I'm currently using 308 in a bolt action (and sometimes an autoloader) and plan to stick with it. I have a 300 wm, but havent shot a deer with it yet. Might use it on a long shot where I have the right setup, an open field, something to rest it on, no need to carry the rifle far (as its a heavy barrel).