IMR 4064 in 52 grains is considered as a pet load for a 150 grains bullet in 30-06. If you can measure your max COL in your rifle, do it and start at around 30 thousands less. if not you can always start with what Nosler provides. If I were you I would load 48, 49, 50, 51, 51.5 and 52 grains, with 3 cartridges for each load. Watch for your groups and for the velocity in addition to signs of high pressure. You want to have good groups, say less than 1.5 inches with good velocity . From a 22 inch barrel you will loose around 50-70 fps relative to a standard 24 in barrel. Nosler brass is excellent but expensive now. I also use Norma brass. 165 grain bullets are excellent for deer. You do not need premium bullets if you hunt deer with a 30-06. I use mainly Sierra bullets in 150 and 165 grains in my Browning BAR. For 150 grains, Big Game powder is unbeatable. For 165 and 180 grains, I use H4350. Sub moa with all loads.