H4350 is a bit slower powder; closer to RL-22, whereas IMR-4350 is closer to RL-19.
Both are excellent, but depending on your load you may have trouble getting enough H4350 into your cases. IMR-4350 results in pretty close to a full case with 180 gr. bullets, and a slightly greater volume of H4350 is required.
The biggest mistake many make is to assume that they are interchangeable because of the similar numbers - they are most assuredly NOT. Using the faster powder in place of the slower powder, grain for grain, can be dangerous.
Handloading isn't (or at least shouldn't be) an attempt to wring the highest possible velocity out of your rifle. If you want more velocity, get a bigger rifle. Handloading should be about consistency, quality and accuracy. Don't worry about "getting another 100 ft/sec." with some other powder. All you'll do is beat up your rifle, shorten your barrel life, and throw your brass away after two firings.....and maybe enjoy a face full of shrapnel, if you insist on pushing things. A .30-06 isn't a .300 Win Mag, but they do sell .300 Win Mags for those who absolutely need another 100 ft./sec.
Just try to load the most consistent, most accurate ammo you can...and I guarantee, eventually you'll end up with a whole cupboard full of different powders.
One rule of thumb that's always worked for me is to use the slowest powder available that will result in a full case, or even in a slightly compressed load. That's usually where the best accuracy will start to show itself. That's why the -4350s work so well in the .30-06, as do RL-19, RL-22 and others in that range.
You might want to dig up a chart of comparative 'speeds' of powders, just to gain some insight. Google will find you several to choose from.
And last but not least READ YOUR MANUAL....or even two or three of them! Especially that seemingly boring first part, before the part where they start listing loads. You'll be surprised how much information there is hidden in there! Fine tuning that perfect load is somewhat trial and error, but the basics principles of handloading should NOT be. And never forget; free advice given by Joe Dink on some internet message board is worth exactly what you paid for it - and it just could get your head blown off, so treat it accordingly.