I use 150 grainers (GMX) in my .300wm, and I use the exact same powder charges as I use in my lead core bonded bullets (accubond, and Hornady interbonds) . The box says to load to same as lead core bullets. (its 95% copper/ 5% zinc Gilding metal construction, so slightly softer than pure copper X bullets, which allows similar powder charges for similar pressures.
The only reason I haven't shot any in my .270 win is because of the glut of ammo I loaded up last fall, and I haven't shot but 20% of it up yet.
I can't wait to put a couple of boxes of GMX's on my shelf in .277
As for actual performance on animals, I have taken a 320lb bear and a male moose I estimate to be around 800 lbs on the hoof (with the .300wm) . Both shots were pass throughs and both animals probably made it a total of 10 yards combined. Wound path and performance seem to be equal to the TSX bullets, so I think they are a win!!