Polygonal rifling is rifling made without the normal land/groove style of twist in the barrel. Imaging that instead of round, the bore of your barrel is an hexagon and they twist it at the rate of normal rifling down the barrel. (or octagon, or pentagon, it's all the same) It's not a new idea, whitworth rifles of the pre civil war period used polygonal rifling, but they had to cut rather then hammer forge so it was much harder to produce.
As suggested above, it's hammer forged and this process tends to give it a very smooth surface finish. The main idea behind it is a forming a highly efficient gas seal, and lower friction twist medium then standard rifling. It also tends to be easier to clean, no sharp corners you have to dig fouling out of, not that this is usually an issue at hand gun velocities. It also tends to have a very long service life.
If you pick a good bullet with a good lube, you'll probably never see any leading worth noting. Too hard a bullet, or a poor lube (too hard) or a lead bullet pushed to fast will start to deposit leading. Because of the nature of polygonal rifling, once it starts to lead, it will begin to lead faster. If it leads enough, you can decrease the bore diameter to the point that the pressure is well above normal due to the added resistance trying to shove a bullet down a smaller hole. This can lead to a kaboom event in the worst circumstances. You have to be pretty oblivious to let this happen, but there are lots of dumb folk out there.
Some like to shoot a few FMJ bullets after shooting a bunch of lead..the idea is the FMJ scrapes the lead out. I don't like this practice, but others swear by it. <shrug>
Go ahead and shoot lead, just clean as it needs it. If your glock is leading up fast, try a different cast bullet. I prefer a softer lead and lube, and have good results.