I shot a bunch of Yotes with 70gr Ballistic Tips. Those things kill like the hammer of Thor and they are decent for distance too. I've shot them out to 700 yds in my 6BR.
A big case like 243 isn't the greatest for lightweight bullets. It would be better served with heavier, ballistically slipperier bullets for longer shots. Something like a 20 or 17 cal wold be the thing for close in yotes.