Osborne, yeah, the 453 Varmint has two action screws. And I believe there are more than a few people that have done away with the barrel lug on their 452 Varmint after bedding it. Can probably find some info here or rimfire central about it.
Crunchiespg, the 453 Varmint has the same layout as the American, two action screws and no barrel lug. It's the 452 Varmint (and some other 452s) that have the single action screw and barrel lug. I think that in 'barrel lug versus no barrel lug' that the one with no barrel lug will win out. It's an advantage over having the lug, though it may take some other doings (bedding, etc) before the lug vs no-lug rears its head. But, never the less, it is a disadvantage to have the barrel lug since the barrel isn't completely free-floated in that case. Some seem to think that the theoretical advantage isn't large enough to show itself in practice with these guns, but I don't belong to that camp. I think a possibility is that the difference might be small enough that it might not matter unless you do all the other accurizing routines as perfectly as possible, or it may be more obvious than that too. But it is at the very least a theoretical advantage that I wanted to have in my rifle, and so I went with the 453 Varmint instead of the 452 Varmint as a result. (As well as choosing the 453's better trigger.)