Some fair questions: so I have read a number of books including “the Nosler” and also have shadowed a friend a number of times. I have a solid and safe location I can set up.
Looking at rifle only, for now 100 rounds a week.
A 100 rounds a week - that's over 5,000 rounds a year if your estimate is correct. So I'm going to assume that you would quickly tire of doing all of that in a single stage press. Let's say with all the handling between depriming and resizing, trimming, priming, measuring out the charge, seating the bullet, etc. that it takes you two minutes per round. What's that - about 173 hours of reloading a year? Over four 40 hour work weeks equivalent?
I think for 100 rounds a week you're thinking either a turret press or a progressive press. If you're fairly certain of loading/shooting in those quantities, I'd suggest you consider a Dillon - especially if you're thinking of expanding your reloading in the future to other calibers, handgun, etc. There's world class F Class/Precision Rifle competitors that do their reloading on Dillons.
I would decide how much my time is worth: would I rather be reloading, or shooting at the range (or doing something else)? For many people who have overtime as an opportunity at work, time spent working overtime can quickly pay for a faster reloading setup that will give them some of their time back.
There is no right answer. After 50+ years of reloading, and an initial period of upgrading my single stage press to finally being a Bonanza Co-Ax, I am now in the school of "Buy once, cry once". Now, it's only the rounds intended for hunting (and load development) that go through the Co-Ax. Everything else: that's what the Dillon 650 is for. At my age, I don't have enough time left to spend more of it in the basement reloading than is necessary. Should be out shooting, hunting, flyfishing, or anything else instead.
At worst, if you decide it isn't for you, it's a lot easier selling high end equipment and at a better percentage of what you initially paid for it, than entry level equipment.